Christophe Le Friant began DJing in the 1980s under the name Chris the French Kiss. During this time he was more influenced by hip-hop and jazz music and created music projects such as The Mighty Bop and Reminiscence Quartet, this one with an ensemble of musicians. Le Friant used the alias Desmond K in the Reminiscence Quartet.
Le Friant adopted the new name of Bob Sinclar in 1998 (hero from the film Le Magnifique). He became known for popularising the "French touch" of house music with heavy use of sampled and filtered disco strings. He describes his musical style as inspired by "peace, love, and house music".
In the 2000s, Several of Sinclar's songs have become international hits, being particularly popular in Europe. Some of his most popular hits include "Love Generation" (2005, with Gary Pine) and "World, Hold On (Children of the Sky)" (2006, featuring Steve Edwards). In 2006, Bob Sinclar received the TMF Award Best Dance International (Belgium). In 2006, he released the song "Rock This Party" under the label Defected Records. In 2008, Bob Sinclar along with Steve Edwards released a song called "Together".
In the 2010s, Bob Sinclar is a very prolific music producer. In 2011 he released a song with the Italian vocalist Raffaella Carrà called "Far l'amore", a remixed version of Carrà's song "A far l'amore comincia tu". In 2013, he released a single called "Summer Moonlight". In 2015, he collaborated with Dawn Tallman for a track entitled "Feel the Vibe". In 2016, he released the track "Someone Who Needs Me" under the label Spinnin' Records. Also with Spinnin' Records, he released a collaboration with Akon entitled "'Til the Sun Rise Up". In June 2018, he released a single called "I Believe", that was very popular, particularly in Italy and Europe.